Frailty and failure to thrive
Citation: Fried LP, Walston J. Frailty and failure to thrive. In: Hazzard WR, Blass JP, Ettinger WH Jr, Halter JB, Ouslander J, eds. Principles of Geriatric Medicine and Gerontology, 4th Ed. […]
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Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial
/by adminIn the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the “Sarcopenia and Physical Frailty […]
Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
/by adminFrailty is a state of health signified by an increased vulnerability to adverse health outcomes in the face of stressors (e.g. infection). There is emerging consensus that research on both […]
Frailty in Older Persons
/by adminCitation: Ferrucci L, Windham BG, Fried LP. Frailty in Older Persons. Genus, 2005; 61(1): 39–53
Dynamics of stability: the physiologic basis of functional health and frailty
/by adminUnder basal resting conditions most healthy physiologic systems demonstrate highly irregular, complex dynamics that represent interacting regulatory processes operating over multiple time scales. These processes prime the organism for an […]
Accumulation of deficits as a proxy measure of aging
/by adminThis paper develops a method for appraising health status in elderly people. A frailty index was defined as the proportion of accumulated deficits (symptoms, signs, functional impairments, and laboratory abnormalities). […]
The physics of frailty
/by adminThe contribution of frailty to human morbidity and mortality is immense. Yet it lacks a conceptual framework. By borrowing from the hypotheses provided by the thermophysicists, frailty can be understood […]
Preventing frail health
/by adminFrailty is a state of reduced physiologic reserve associated with increased susceptibility to disability. Reduced physiologic capacity in neurologic control, mechanical performance, and energy metabolism are the major components of […]