Biological Basis of Frailty

Connecting age-related biological decline to frailty and late-life vulnerability. Frailty: pathophysiology, phenotype and patient care.
Walston, Jeremy D

The biology of aging and frailty
Fedarko NS

Inflammation, coagulation, and the pathway to frailty
Kanapuru B, Ershler WB

Biological markers and the molecular biology of frailty. Longevity and frailty.
Walston, Jeremy D

Biomarkers of frailty in older persons
Ferrucci L, Cavazzini C, Corsi A, et al.

Conceptual Models

Frailty and failure to thrive
Fried LP, Walston J

Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial
Cesari M, Landi F, Calvani R, et al

Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
Varadhan R, Seplaki CL, Xue QL, Bandeen-Roche K, Fried LP

Frailty in Older Persons
Ferrucci L, Windham BG, Fried LP

Dynamics of stability: the physiologic basis of functional health and frailty
Lipsitz LA

Accumulation of deficits as a proxy measure of aging
Mitnitski AB, Mogilner AJ, Rockwood K

The physics of frailty
Bortz WM 2nd

Preventing frail health
Buchner DM, Wagner EH.


Dissecting the Racial/Ethnic Disparity in Frailty in a Nationally Representative Cohort Study with Respect to Health, Income, and Measurement
Usher T, Buta B, Thorpe RJ, et al.

Prevalence of Frailty in Latin America and the Caribbean: A Systematic Review and Meta-Analysis
Da Mata FAF, Pereira PPdS, Andrade KRCd, Figueiredo ACMG, Silva MT, et al.

Frailty in Older Adults: A Nationally Representative Profile in the United States
Bandeen-Roche K, Seplaki CL, Huang J, et al.

Prevalence of frailty in community-dwelling older persons: a systematic review
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC


Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies
Puts MTE, Toubasi S, Andrew MK, et al.

The effectiveness of exercise interventions for the management of frailty: a systematic review
Theou O, Stathokostas L, Roland KP, et al.

Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
Ferrucci L, Guralnik JM, Studenski S, et al.

Frailty Screening and Interventions: Considerations for Clinical Practice
Walston J, Buta B, Xue QL

Methodology, Deficit Accumulation Assessment

A standard procedure for creating a frailty index
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K.

Frailty in relation to the accumulation of deficits
Rockwood K, Mitnitski A.

Methodology, Physical Frailty Assessment

Phenotype of frailty: characterization in the women’s health and aging studies
Bandeen-Roche K, Xue QL, Ferrucci L, et al.

Frailty in older adults: evidence for a phenotype
Fried LP, Tangen CM, Walston J, et al.

Methodology, Pre-disability Assessment

Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial
Cesari M, Landi F, Calvani R, et al

Methodology, Reviews of Frailty Instruments

Frailty measurement in research and clinical practice: A review
Dent E, Kowal P, Hoogendijk EO

Frailty assessment instruments: Systematic characterization of the uses and contexts of highly-cited instruments
Buta BJ, Walston JD, Godino JG, et al.

Measures of frailty in population-based studies: an overview
Bouillon K, Kivimaki M, Hamer M, et al.

The identification of frailty: a systematic literature review
Sternberg SA, Wershof Schwartz A, Karunananthan S, Bergman H, Mark Clarfield A.

Outcome instruments to measure frailty: a systematic review
de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JS, Olde Rikkert MG, Nijhuis-van der Sanden MW.

Toward a conceptual definition of frail community dwelling older people
Gobbens RJ, Luijkx KG, Wijnen-Sponselee MT, Schols JM.

Methodology, Validation

Discrepancy in Frailty Identification: Move Beyond Predictive Validity
Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K.

Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity?
Xue QL, Tian J, Fried LP, et al.

What would make a definition of frailty successful?
Rockwood K

Principles and Issues for Physical Frailty Measurement and Its Clinical Application
Bandeen-Roche K, Gross AL, Varadhan R, et al.

Overviews of Frailty: research and clinical applications

Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference
Walston J, Robinson TN, Zieman S, et al.

Frailty consensus: a call to action
Morley JE, Vellas B, van Kan GA, et al.

Frailty in elderly people
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K

Frailty: a review of the first decade of research
Zaslavsky O, Cochrane BB, Thompson HJ, Woods NF, Herting JR, LaCroix A

The frailty syndrome: definition and natural history
Xue QL

Frailty: an emerging research and clinical paradigm–issues and controversies
Bergman H, Ferrucci L, Guralnik J, et al.

Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults.
Walston J, Hadley EC, Ferrucci L, et al.

From bedside to bench: research agenda for frailty.
Fried LP, Hadley EC, Walston JD, et al.

Models, definitions, and criteria of frailty
Hogan DB, MacKnight C, Bergman H; Steering Committee, Canadian Initiative on Frailty and Aging.

Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary
Walston J, Bandeen-Roche K, Buta B, et al.


Physical Resilience: Not Simply the Opposite of Frailty
Whitson HE, Cohen HJ, Schmader KE, Morey MC, Kuchel G, Colon-Emeric CS

Can a Link Be Found Between Physical Resilience and Frailty in Older Adults by Studying Dynamical Systems?
Varadhan R, Walston JD, Bandeen-Roche K

Quantifying resilience of humans and other animals
Scheffer M, Bolhuis JE, Borsboom D, et al.

Physical Resilience: Opportunities and Challenges in Translation
LeBrasseur NK

Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Hadley EC, Kuchel GA, Newman AB

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct
Whitson HE, Duan-Porter W, Schmader KE, Morey MC, Cohen HJ, Colón-Emeric CS