This post envisions a lively debate about the pros and cons of using Mendelian randomization to advance causal inference in frailty research. By Qian-Li Xue, PhD
A simple question – “How would you rate your health?” – might seem too subjective to matter in modern medicine. But evidence is increasingly telling us otherwise.
Frailty and cognitive impairment, two common geriatric conditions, are known to be associated with late-life vulnerability in older adults. An estimated 15% of non-nursing home older adults in the United States aged 65 and over are frail, and about 22% and 9% have mild cognitive impairment and dementia. Physical frailty and cognitive impairment often co-exist in older adults. However, there are sizeable subgroups who have one but not the other. Continue Reading