Biological Basis of Frailty
Connecting age-related biological decline to frailty and late-life vulnerability. Frailty: pathophysiology, phenotype and patient care.Walston, Jeremy D
The biology of aging and frailty
Fedarko NS
Inflammation, coagulation, and the pathway to frailty
Kanapuru B, Ershler WB
Biological markers and the molecular biology of frailty. Longevity and frailty.
Walston, Jeremy D
Biomarkers of frailty in older persons
Ferrucci L, Cavazzini C, Corsi A, et al.
Conceptual Models
Frailty and failure to thriveFried LP, Walston J
Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial
Cesari M, Landi F, Calvani R, et al
Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
Varadhan R, Seplaki CL, Xue QL, Bandeen-Roche K, Fried LP
Frailty in Older Persons
Ferrucci L, Windham BG, Fried LP
Dynamics of stability: the physiologic basis of functional health and frailty
Lipsitz LA
Accumulation of deficits as a proxy measure of aging
Mitnitski AB, Mogilner AJ, Rockwood K
The physics of frailty
Bortz WM 2nd
Preventing frail health
Buchner DM, Wagner EH.
Epidemiology/Disparities
Dissecting the Racial/Ethnic Disparity in Frailty in a Nationally Representative Cohort Study with Respect to Health, Income, and MeasurementUsher T, Buta B, Thorpe RJ, et al.
Prevalence of Frailty in Latin America and the Caribbean: A Systematic Review and Meta-Analysis
Da Mata FAF, Pereira PPdS, Andrade KRCd, Figueiredo ACMG, Silva MT, et al.
Frailty in Older Adults: A Nationally Representative Profile in the United States
Bandeen-Roche K, Seplaki CL, Huang J, et al.
Prevalence of frailty in community-dwelling older persons: a systematic review
Collard RM, Boter H, Schoevers RA, Oude Voshaar RC
Interventions
Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policiesPuts MTE, Toubasi S, Andrew MK, et al.
The effectiveness of exercise interventions for the management of frailty: a systematic review
Theou O, Stathokostas L, Roland KP, et al.
Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
Ferrucci L, Guralnik JM, Studenski S, et al.
Frailty Screening and Interventions: Considerations for Clinical Practice
Walston J, Buta B, Xue QL
Methodology, Deficit Accumulation Assessment
A standard procedure for creating a frailty indexSearle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K.
Frailty in relation to the accumulation of deficits
Rockwood K, Mitnitski A.
Methodology, Physical Frailty Assessment
Phenotype of frailty: characterization in the women’s health and aging studiesBandeen-Roche K, Xue QL, Ferrucci L, et al.
Frailty in older adults: evidence for a phenotype
Fried LP, Tangen CM, Walston J, et al.
Methodology, Pre-disability Assessment
Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trialCesari M, Landi F, Calvani R, et al
Methodology, Reviews of Frailty Instruments
Frailty measurement in research and clinical practice: A reviewDent E, Kowal P, Hoogendijk EO
Frailty assessment instruments: Systematic characterization of the uses and contexts of highly-cited instruments
Buta BJ, Walston JD, Godino JG, et al.
Measures of frailty in population-based studies: an overview
Bouillon K, Kivimaki M, Hamer M, et al.
The identification of frailty: a systematic literature review
Sternberg SA, Wershof Schwartz A, Karunananthan S, Bergman H, Mark Clarfield A.
Outcome instruments to measure frailty: a systematic review
de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JS, Olde Rikkert MG, Nijhuis-van der Sanden MW.
Toward a conceptual definition of frail community dwelling older people
Gobbens RJ, Luijkx KG, Wijnen-Sponselee MT, Schols JM.
Methodology, Validation
Discrepancy in Frailty Identification: Move Beyond Predictive ValidityXue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K.
Physical Frailty Assessment in Older Women: Can Simplification Be Achieved Without Loss of Syndrome Measurement Validity?
Xue QL, Tian J, Fried LP, et al.
What would make a definition of frailty successful?
Rockwood K
Principles and Issues for Physical Frailty Measurement and Its Clinical Application
Bandeen-Roche K, Gross AL, Varadhan R, et al.
Overviews of Frailty: research and clinical applications
Integrating Frailty Research into the Medical Specialties-Report from a U13 ConferenceWalston J, Robinson TN, Zieman S, et al.
Frailty consensus: a call to action
Morley JE, Vellas B, van Kan GA, et al.
Frailty in elderly people
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K
Frailty: a review of the first decade of research
Zaslavsky O, Cochrane BB, Thompson HJ, Woods NF, Herting JR, LaCroix A
The frailty syndrome: definition and natural history
Xue QL
Frailty: an emerging research and clinical paradigm–issues and controversies
Bergman H, Ferrucci L, Guralnik J, et al.
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults.
Walston J, Hadley EC, Ferrucci L, et al.
From bedside to bench: research agenda for frailty.
Fried LP, Hadley EC, Walston JD, et al.
Models, definitions, and criteria of frailty
Hogan DB, MacKnight C, Bergman H; Steering Committee, Canadian Initiative on Frailty and Aging.
Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary
Walston J, Bandeen-Roche K, Buta B, et al.
Resiliency
Physical Resilience: Not Simply the Opposite of FrailtyWhitson HE, Cohen HJ, Schmader KE, Morey MC, Kuchel G, Colon-Emeric CS
Can a Link Be Found Between Physical Resilience and Frailty in Older Adults by Studying Dynamical Systems?
Varadhan R, Walston JD, Bandeen-Roche K
Quantifying resilience of humans and other animals
Scheffer M, Bolhuis JE, Borsboom D, et al.
Physical Resilience: Opportunities and Challenges in Translation
LeBrasseur NK
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Hadley EC, Kuchel GA, Newman AB
Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct
Whitson HE, Duan-Porter W, Schmader KE, Morey MC, Cohen HJ, Colón-Emeric CS